Amorphous solid dispersions (ASDs) are often used for formulating poorly water-soluble
active pharmaceutical ingredients (APIs). In an ASD, the amorphous API is embedded in a
suitable matrix excipient in order to stabilize the amorphous state and control the dissolution
performance. ASDs can be prepared by commonly dissolving the API and the polymer in a
suitable organic solvent which is evaporated afterward (eg, via spray drying) aiming at a
homogeneous API distribution in the polymer matrix. Sometimes, unexpected solvent …